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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Adipose-derived mesenchymal stem cells attenuate dialysis-induced peritoneal fibrosis by modulating macrophage polarization via interleukin-6

Fig. 7

IL-6 neutralization downregulated macrophage iNOS and Arg-1 gene expression. NR8383 macrophages were treated with LPS plus ADSC-CM or BM-MSC-CM with/without IL-6 neutralizing antibody (1.0 μg/mL) for 3 days. The cells were analyzed by qPCR for iNOS (a) and Arg-1 (b) mRNA. Data were presented as mean ± SEM. ANOVA, p < 0.05, different characters represent different levels of significance. Abbreviations: BM-MSC bone marrow-derived mesenchymal stem cell, ADSC adipose-derived mesenchymal stem cell, iNOS inducible nitric oxide synthase, Arg-1 arginase-1, TGF-β1 transforming growth factor-beta 1, LPS lipopolysaccharides, IL-6 Ab interleukin-6 neutralizing antibody

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Stem Cell Research & Therapy

ISSN: 1757-6512