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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Human placenta mesenchymal stem cell-derived exosomes delay H2O2-induced aging in mouse cholangioids

Fig. 6

Exosomes reduced the expression of SASP components and chemokines in senescent cholangioids. a mRNA expression levels of SASP components (IL-6, CCL2, CXCL2, CXCL9, CXCL16, CX3CL1, and CXCL1), which decreased significantly at 120 h in the Exo group compared with the Sen group. Data are presented as mean ± SD (n = 4). b Fold changes of CXCL10 mRNA expression in organoids at different time points. Data are presented as mean ± SD (n = 4). c Tumor necrosis factor-α protein concentrations in culture supernatant at 24, 48, 96, and 120 h. Data are presented as mean ± SD (n = 3). dg IL-6, CCL2, CXCL1, and CXCL10 protein concentrations in culture supernatant at 120 h, which were significantly decreased in the Exo group compared with the Ctrl and Sen groups. Data are presented as mean ± SD (n = 3). One-way ANOVA, ***P < 0.001, **P < 0.01, *P < 0.05

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