From: Advances in intranasal application of stem cells in the treatment of central nervous system diseases
Authors | Year | Animal models | Cell types | Results |
---|---|---|---|---|
Danielyan et al. [62] | 2014 | APP/PS1 mouse model | BM-MSC-derived macrophages | At 7 days after INA, macrophages induced by BM-MSCs were detected in different brain regions affected by Aβ plaque pathology |
Mita et al. [65] | 2015 | Aβ1–40-peptide induced mouse model | SHED-CM | Cognitive function effectively improved. Reduced proinflammatory response of Aβ. Created anti-inflammatory/tissue regeneration environment. Induced formation of the anti-inflammatory M2-like microglia. |
Harach et al. [66] | 2016 | APP/PS1 mouse model | Soluble molecules of hMSC | Ten weeks INA, the level of Aβ was effectively reduced. Continuous intranasal injection of soluble factor of hMSC also reduced amyloidosis in mice brain. |
Perets et al. [67] | 2019 | 5xFAD transgenic mouse model | Exosomes of MSCs | Exosomes were observed to accumulate near Aβ plaques within 96 h after INA. |