Table 3 Challenges of stem cells translation from animal experiments to clinical application via INA
From: Advances in intranasal application of stem cells in the treatment of central nervous system diseases
Challenges | Solutions |
|---|---|
Long-term therapeutic effect of cell transplantation | Long-term observations of therapeutic effect in different animal models |
Optimum cell quantity | Different optimal cell sizes need to be found under different models |
Long-term safety of cell transplantation | Long-term observations of side effect in different animal models (such us oncogenicity) |
Appropriate disease type | Explore more possible treatments for neurological diseases |