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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Human placental mesenchymal stem cells ameliorate chemotherapy-induced damage in the testis by reducing apoptosis/oxidative stress and promoting autophagy

Fig. 3

In cultured Sertoli cells treated with busulfan, hPMSCs inhibited cell apoptosis and enhanced cell proliferation. a The FACS results indicated that hPMSC treatment inhibited the rate of apoptosis (Annexin V) in Sertoli cells. b The FACS results showed that hPMSC treatment improved the proliferation rate (Ki67) of Sertoli cells. c, d The qRT-PCR results showed that hPMSC treatment suppressed the expression of apoptotic genes (γ-H2AX, BRCA1, and PARP1) and increased the expression of proliferative genes (PCNA and Ki67). All experiments were carried out three times, and the error bars indicate the SD. **p < 0.01, ***p < 0.001

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