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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Lyophilized powder of mesenchymal stem cell supernatant attenuates acute lung injury through the IL-6–p-STAT3–p63–JAG2 pathway

Fig. 6

MSC SLP inhibited STAT3 phosphorylation, and rh IL-6 enhanced STAT3 phosphorylation to reduce p63 expression. a The levels of p-STAT3, STAT3, and β-actin proteins were measured by western blotting. b Quantitative analysis of p-STAT3 expression. c The concentrations of rh IL-6 in the lungs on days 1 and 2 after rh IL-6 administration. d The protein levels of p-STAT3, STAT3, p63, and β-actin were measured by western blotting. e Quantitative analysis of p-STAT3 expression. f p63 mRNA-expression levels were measured by RT-qPCR. N = 6–8 in each group. The data shown are presented as the mean ± SD, and statistical differences were assessed by one-way ANOVA. **P < 0.01; ***P < 0.001

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