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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Applications and therapeutic mechanisms of action of mesenchymal stem cells in radiation-induced lung injury

Fig. 2

Molecular mechanisms of MSC-based therapy for RILI through the following aspects: reduction of inflammatory and fibrosis reaction; resistance of oxidative stress; inhibition of EMT; immunosuppressive properties; release of extracellular vesicles. EMT, epithelial-to-mesenchymal transition; IL-1β, interleukin 1β; IL-6, interleukin 6; IL-10, interleukin 10; TNF-α, tumor necrosis factor α; SOD1, superoxide dismutase 1; SOD3, superoxide dismutase 3; MnSOD, manganese superoxide dismutase; HGF, hematopoietic growth factor; EVs, extracellular vesicles; PGE2, prostaglandin E2; IDO, indoleamine 2,3-dioxygenase

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