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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Use of constitutive and inducible oncogene-containing iPSCs as surrogates for transgenic mice to study breast oncogenesis

Fig. 3

Select gene expression levels in the different groups by RT-qPCR and Western blot analysis. Strong expression of the iPSC reprogramming genes was in evidence in representative clones but not in the tail vein fibroblasts. During in vivo oncogenesis, the expression of the exogenous pluripotency reprogramming factors no longer occurred but were replaced by strong expression of the oncogenic transgene, e.g., PyVT (PMT) by RT-qPCR (a). The same observations were confirmed by Western blot (b)

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