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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Use of constitutive and inducible oncogene-containing iPSCs as surrogates for transgenic mice to study breast oncogenesis

Fig. 4

Pluripotent differentiation of iPSC clones in vitro. Differentiation of iPSCs into various lineages at different time points is depicted (left). Undifferentiated iPSC clones were induced to differentiate into endothelial cells, depicted at day 7 (a) and then at day 15 (b). Similarly, undifferentiated iPSC clones were induced to differentiate into hepatic cells, depicted at day 7 (d) and at day 15 (e). Additionally, undifferentiated iPSC clones were induced to differentiate into osteocytes, depicted at day 7 (g) and at day 14 (h). Each of the lineage differentiations were confirmed by representative marker studies which included CD31 (endothelial) (c), albumin (hepatic) (f), and osteocalcin (i). Western blot from the lineage-specific differentiated cells confirmed their respective endothelial, hepatic, and osteocyte differentiation (right)

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