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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Combined topical and systemic administration with human adipose-derived mesenchymal stem cells (hADSC) and hADSC-derived exosomes markedly promoted cutaneous wound healing and regeneration

Fig. 2

hADSC-Exo enhance cutaneous wound healing in an in vivo mouse model. a The study protocol. b Representative photographs of full-thickness excision wounds treated with rhEGF (positive control), hADSC, or hADSC-Exo. hADSC-Exo were administered either by sm or sc for 12 days. c Quantitative analysis of wound healing in each group. d H&E staining of wounded skin sections in different groups at day 12 post-wounding. Scale bar = 250 μm. e Masson staining of wounded skin sections in different groups at day 12 post-wounding. Results are presented as mean ± standard error of the mean; n = 8 for each group. *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001 vs vehicle control group. sm smearing administration, sc subcutaneous administration

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