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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Exosomes derived from human adipose mesenchymal stem cells attenuate hypertrophic scar fibrosis by miR-192-5p/IL-17RA/Smad axis

Fig. 4

The effect of ADSC-exosomal miR-192-5p on HSFs. a The expression of miR-192-5p in ADSCs and ADSC-Exo. b qRT-PCR analysis of miR-192-5p in ADSCs transfected with miR-192-5p inhibitor NC or anti-miR-192 and their corresponding ADSC-Exo. c Immunoblot analysis of IL-17RA in HSFs and wound tissues of BALB/c mice exposure to ADSC-Exo or PBS. d Immunoblot analysis of IL-17RA, Col1, Col3, and α-SMA in HSFs stimulated with PBS, ADSC-Exo, ADSC-Exo/anti-miR-192-5p NC, or ADSC-Exo/anti-miR-192-5p, graph showed the relative band density to β-actin. Every experiment was repeated at least three times, and the data was shown as mean ± SEM (*p < 0.05; **p < 0.01)

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