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Table 3 Azoospermia treated with mesenchymal stromal/stem cells in in vivo model studies

From: Mesenchymal stromal/stem cells and their exosomes for restoration of spermatogenesis in non-obstructive azoospermia: a systemic review

Source Transplantation Donor species Therapeutics Recipient species Modeling References
Adipose tissue Allotransplant Hamster Cell Hamster Busulfan [121]
Adipose tissue Allotransplant Mouse Cell
Exosome
Mouse Busulfan [122]
Adipose tissue Allotransplant Rat Cell Rat Busulfan [70, 123, 124]
Adipose tissue Allotransplant Rat Cell Rat Cisplatin [125]
Adipose tissue Xenotransplant Human Cell Rat Torsion [126]
Amnion Allotransplant Mouse Cell Mouse Busulfan [127]
Bone marrow Allotransplant Guinea pig Cell Guinea pig Busulfan [128]
Bone marrow Allotransplant Hamster Cell Hamster Busulfan [129]
Bone marrow Allotransplant Mouse Cell Mouse Busulfan [130, 131]
Bone marrow Allotransplant Mouse Cell
Exosome
Mouse Busulfan [122]
Bone marrow Allotransplant Mouse Cell Mouse Cisplatin [132]
Bone marrow Allotransplant Rat Cell Rat Busulfan [87, 89, 133,134,135,136,137,138]
Bone marrow Allotransplant Rat Cell Rat Doxorubicin [139]
Bone marrow Allotransplant Rat Cell Rat Lead nitrate [140]
Bone marrow Allotransplant Rat Cell Rat Torsion [141]
Bone marrow Xenotransplant Goat Cell Mouse Busulfan [142]
Umbilical cord Xenotransplant Human Cell Mouse Busulfan [143,144,145]
Urine Allotransplant Mouse Cell
Exosome
Mouse Busulfan [146]