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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: MSC-derived small extracellular vesicles overexpressing miR-20a promoted the osteointegration of porous titanium alloy by enhancing osteogenesis via targeting BAMBI

Fig. 8

sEV-20a promotes the migration and osteogenic differentiation of hBM-MSCs through targeting BAMBI. a The protein expression level of BAMBI after the overexpression of BAMBI (+) and treated by sEV and sEV-20a by Western blot. b The proliferation of hBM-MSCs overexpressing BAMBI incubated with sEV and sEV-20a by CCK-8 assay. c-d Cell migration of hBM-MSCs overexpressing BAMBI cultured with sEV and sEV-20a by transwell assay. Scale bar = 100 μm. ALP staining and ARS for the assessment of osteogenic differentiation of hBM-MSCs overexpressing BAMBI cultured with sEV and sEV-20a. Scale bar = 200 μm. e-g Relative gene expression of ALP, RUNX2, OCN of hBM-MSCs overexpressing BAMBI treated with sEV and sEV-20a. GAPDH was used for normalization (n = 3, *p < 0.05)

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Stem Cell Research & Therapy

ISSN: 1757-6512