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Table 4 Outcomes (immune reconstitution) of included studies

From: Efficacy and safety of mesenchymal stem cells co-infusion in allogeneic hematopoietic stem cell transplantation: a systematic review and meta-analysis

Study

Outcome

HSCT+MSCs group

HSCT group

Time points

p value

Ball et al. [16]

NK cells (× 109/L)

0.497, 95% CI 0.347–0.646

0.252, 95% CI 0.173–0.33

28 days

= 0.02*

WBC > 1 × 109/L (days)

11.5, 95% CI 9.0–14.8

14.9, 95% CI 10.1–26.0

NA

= 0.009*

NK and T cells

NA

NA

3 months

NS

Liu et al. [22]

WBC (days)

12 (10–21)

12 (10–23)

NA

NS

Ghavamzadeh et al. [33]

WBC > 0.5 × 109/L (days)

17.7 (15–20)

17.7 (15–20)

NA

= 0.83

Mareika et al. [29]

(NK) cells (× 109/L)

0.1 (0.02–0.23)

0.01 (0.002–0.06)

100 days

= 0.07

B cells (× 109/L)

0.18 (0.11–0.43)

0.07 (0.02–0.19)

100 days

= 0.05*

Lee et al. [14]

Lymphocyte subpopulations

NA

NA

28, 100, 180 and 365 days

NS

Gonzalo-Daganzo et al. [30]

Lymphocyte subpopulations

NA

NA

NA

NS

Baron et al. [32]

T cells (× 109/L)

0.29 (0.00 4–0.54)

0.202 (0.041–0.886)

28 days

NS

Wu et al. [34]

Absolute lymphocyte count (× 109/L)

0.305 (0.196–0. 445)

0.256 (0.150–0.368)

30 days

= 0.35

Xiang [13]

The levels of serum immunoglobulins IgA, IgG, IgM, and IgE

1, 3, and 6 months

< 0.05*

The levels of T lymphocytes and B cells

  1. NA not available, NS not significant
  2. *Statistically significant