Table 6 Summarized results of the subgroup analysis
Outcome or subgroup | ANC | PLT | aGVHD | cGVHD | OS | RR | NRM | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of studies | Sample size | SMD (95% CI) | P | No. of studies | Sample size | SMD (95% CI) | P | No. of studies | Sample size | RR (95% CI) | P | No. of studies | Sample size | RR (95% CI) | P | No. of studies | Sample size | HR (95% CI) | P | No. of studies | Sample size | RR (95% CI) | P | No. of studies | Sample size | OR (95% CI) | P | |
Subtotal | 14 | 471 | − 0.77 (− 1.29, − 0.26) | < 0.01* | 14 | 538 | − 0.66 (− 1.06, − 0.27) | < 0.01* | 12 | 475 | 0.77 (0.64, 0.92) | < 0.01* | 14 | 535 | 0.51 (0.37, 0.70) | < 0.01* | 10 | 395 | 0.88 (0.59, 1.33) | 0.54 | 9 | 370 | 0.96 (0.66, 1.41) | 0.84 | 6 | 197 | 0.33 (0.16, 0.71) | < 0.01* |
Type of disease | ||||||||||||||||||||||||||||
 Hematologic malignant | 10 | 367 | − 0.54 (− 1.14, 0.06) | 0.08 | 9 | 364 | − 0.28 (− 0.61, 0.04) | 0.09 | 8 | 316 | 0.77 (0.63, 0.95) | 0.02* | 9 | 361 | 0.51 (0.35, 0.75) | < 0.01* | 9 | 381 | 0.85 (0.56, 1.30) | 0.45 | 9 | 370 | 0.96 (0.66, 1.41) | 0.84 | 5 | 183 | 0.34 (0.16, 0.73) | < 0.01* |
 Nonmalignant disorders | 1 | 14 | − 2.09 (− 3.47, − 0.70) | < 0.01* | 2 | 84 | − 1.64 (− 2.15, − 1.14) | < 0.01* | 2 | 84 | 0.83 (0.58, 1.21) | 0.34 | 2 | 84 | 0.58 (0.32, 1.06) | 0.08 | 0 | 0 | NA | NA | 0 | 0 | NA | NA | 0 | 0 | NA | NA |
 Mixed | 3 | 90 | − 1.39 (− 2.86, 0.07) | 0.06 | 3 | 90 | − 1.41 (− 2.79, − 0.03) | 0.05* | 2 | 75 | 0.53 (0.21, 1.33) | 0.17 | 3 | 90 | 0.38 (0.11, 1.28) | 0.12 | 1 | 14 | 1.68 (0.27, 10.44) | 0.58 | 0 | 0 | NA | NA | 1 | 14 | 0.27 (0.01, 6.89) | 0.43 |
HLA matching | ||||||||||||||||||||||||||||
 Identical | 2 | 88 | − 0.79 (− 3.02, 1.45) | 0.49 | 2 | 134 | − 0.94 (− 2.36, 0.49) | 0.2 | 2 | 94 | 0.79 (0.56, 1.11) | 0.18 | 3 | 155 | 0.43 (0.22, 0.84) | 0.01* | 2 | 89 | 2.95 (1.05, 8.25) | 0.04* | 2 | 89 | 1.34 (0.29, 6.25) | 0.71 | 1 | 25 | 0.72 (0.06, 9.22) | 0.80 |
 Non-identical | 10 | 346 | − 0.63 (− 1.18, − 0.07) | 0.03* | 10 | 367 | − 0.50 (− 0.93, − 0.07) | 0.02* | 10 | 381 | 0.76 (0.61, 0.94) | 0.01* | 10 | 365 | 0.56 (0.39, 0.81) | < 0.01* | 8 | 306 | 0.70 (0.45, 1.10) | 0.12 | 6 | 259 | 0.81 (0.51, 1.28) | 0.37 | 5 | 172 | 0.31 (0.14, 0.68) | < 0.01* |
 Not reported | 2 | 37 | − 1.30 (− 2.03, − 0.57) | < 0.01* | 2 | 37 | − 1.02 (− 1.77, − 0.26) | < 0.01* | 0 | 0 | NA | NA | 1 | 15 | 0.16 (0.01, 2.66) | 0.20 | 0 | 0 | NA | NA | 1 | 22 | 3.55 (0.16, 78.56) | 0.42 | 0 | 0 | NA | NA |
Average age | ||||||||||||||||||||||||||||
 ≤ 18 years | 8 | 279 | − 1.07 (− 1.84, − 0.31) | < 0.01* | 7 | 249 | − 0.71 (− 1.22, − 0.19) | < 0.01* | 6 | 209 | 0.64 (0.47, 0.87) | < 0.01* | 7 | 276 | 0.43 (0.23, 0.84) | 0.01* | 5 | 175 | 0.94 (0.39, 2.22) | 0.88 | 5 | 205 | 0.79 (0.49, 1.30) | 0.36 | 3 | 81 | 0.19 (0.05, 0.68) | 0.01* |
 > 18 years | 6 | 192 | − 0.37 (− 1.00, 0.26) | 0.25 | 6 | 219 | − 0.35 (− 0.86, 0.17) | 0.19 | 5 | 196 | 0.85 (0.65, 1.12) | 0.25 | 6 | 189 | 0.54 (0.36, 0.81) | < 0.01* | 5 | 220 | 1.01 (0.44, 2.30) | 0.98 | 4 | 165 | 1.25 (0.68, 2.31) | 0.47 | 3 | 116 | 0.46 (0.18, 1.18) | 0.11 |
 Not reported | 0 | 0 | NA | NA | 1 | 70 | − 1.67 (− 2.22, − 1.11) | < 0.01* | 1 | 70 | 0.86 (0.59, 1.25) | 0.42 | 1 | 70 | 0.58 (0.28, 1.21) | 0.15 | 0 | 0 | NA | NA | 0 | 0 | NA | NA | 0 | 0 | NA | NA |