Fig. 3From: Bone marrow mesenchymal stem cell exosomes suppress phosphate-induced aortic calcification via SIRT6–HMGB1 deacetylationDeposition of Ca in the aorta of a chronic kidney disease (CKD) mouse model. CKD mice were placed on a high-phosphate diet for 12 weeks with either PBS or exosome treatment. a Representative micrographs of HE stained sections of the aortas. Scale bar = 200 μm or 50 μm. b Representative micrographs of Alizarin Red stained sections of the aortas. Scale bar = 100 μm or 50 μm. c Calcium and d phosphorus content in the thoracic aortas. e Western blot analysis of osteopontin, Runx2, and Msx2 in the aortas of sham-operated and CKD mice. Quantification of osteopontin (f) Runx2 (g), and Msx2 (h) expression relative to that of β-actin. n = 6 per group. Data are presented as the mean ± SD. *p < 0.05, **p < 0.01, compared with the sham group. #p < 0.05 compared with the PBS groupBack to article page