Fig. 7
From: TRPC7 regulates the electrophysiological functions of embryonic stem cell-derived cardiomyocytes
Knockdown of TRPC7 decreased while overexpression of TRPC7 increased the NCX current (INCX) in mESC-CMs. a Current density-voltage relationship of INCX recorded from knockdown control mESC-CMs (red curve) and TRPC7-knockdown mESC-CMs (green curve). b Current density-voltage relationship of INCX recorded from overexpression control mESC-CMs (blue curve) and TRPC7-overexpression mESC-CMs (orange curve). Bar charts showing the statistics of NCX current density measured at + 50 mV and − 100 mV from c, d, the knockdown experiment, and e, f the overexpression experiment. Knockdown of TRPC7 decreased while overexpression of TRPC7 increased the outward INCX at + 50 mV and inward INCX at − 100 mV. Data were presented as mean ± SEM (n = 14–15 cells; cells were from 5 independent batches of differentiation). *P < 0.05, **P < 0.01 vs corresponding controls