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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Hypoxic preconditioning induces epigenetic changes and modifies swine mesenchymal stem cell angiogenesis and senescence in experimental atherosclerotic renal artery stenosis

Fig. 3

Hypoxia upregulated pro-angiogenic protein and gene expression in MSC. VEGF release by swine MSC was low in ARAS compared to healthy pigs and augmented but not normalized during hypoxia (a). EGF secretion was elevated in ARAS in comparison to healthy MSC (b). Hypoxia upregulated pro-angiogenic genes (VEGF-a) in healthy and ARAS MSC (c), as well as EGF gene expression in ARAS (D). *p < 0.05 hypoxia vs normoxia. †p < 0.05 ARAS vs healthy

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Stem Cell Research & Therapy

ISSN: 1757-6512