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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: PINK1 contained in huMSC-derived exosomes prevents cardiomyocyte mitochondrial calcium overload in sepsis via recovery of mitochondrial Ca2+ efflux

Fig. 1

HuMSC-exos showed cardioprotective effects in septic mice. ac Characterizations of exosomes derived from huMSCs. a Electron micrographs of huMSCs exosomes. b The size of huMSC exosomes measured using a particle size analyzer. c Exosome markers detected by Western blot. d Detection of myocardial injury serological markers HBDH, CK, and cTnI; *p < 0.05, **p < 0.01, ****p < 0.0001 when compared between mice 12 h after CLP and the huMSC-exo treatment group. e Representative echocardiography of the sham, CLP 12 h, and CLP 12 h + exo groups. f Measurement of ejection fraction; **p < 0.01 vs. sham group, ##p < 0.01 vs. CLP 12 h group. g Survival in mice following huMSC-exo treatment after CLP. Comparisons between groups were performed using Kaplan-Meier analysis followed by log-rank tests; ***p < 0.001 vs. CLP group

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