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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: PINK1 contained in huMSC-derived exosomes prevents cardiomyocyte mitochondrial calcium overload in sepsis via recovery of mitochondrial Ca2+ efflux

Fig. 4

Sepsis decreased the expression of PINK1 in cardiomyocytes, and huMSC-exo transferred Pink1 mRNA into cardiomyocytes to increase PINK1 expression. a Western blot detected PINK1 expression in hearts 12 h after CLP and after treatment with huMSC-exo; GAPDH was used as a loading control. b, c The relative expression of Pink1 mRNA in huMSCs, huMSC-exo (b) and huMSCs, huMSC-exo transfected with siRNA (c); **p < 0.01 vs. huMSCs group, ****p < 0.0001 vs. Neg siRNA group. d Western blot analysis of PINK1 expression in the heart 12 h after CLP and after treatment with huMSC-exo or huMSC-exo transfected with siRNA; GAPDH was used as a loading control

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