Fig. 3

Modeling GBA biology in the nigrostriatal niche. Schematic representation of co-culture modeling for GBA study. The model presented can be used to determine cell-type-specific phenotypes associated with GBA misexpression. Astrocyte (purple) and microglia (green) strictly control neuronal homeostasis. Co-culture models allow for the assessment of neuroimmune interactions, metabolic support, and inflammatory response (left panel) as well as phagocytic and aggregates-clearance function (right panel). The model opens the possibility to perform the study in a physiologically relevant environment and evaluate how GCase dysfunction in a specific cell type impacts other components of the model