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Table 3 Neurodegenerative disease unique protein aggregates and neuronal susceptibility

From: Towards physiologically relevant human pluripotent stem cell (hPSC) models of Parkinson’s disease

 

Protein inclusion

Most vulnerable neuronal population

Alzheimer’s disease

Neurofibrillary tangles (phosphorylated tau); amyloid plaques (amyloid β peptide)

Pyramidal neurons (entorhinal cortex, hippocampus, locus coeruleus)

Parkinson’s disease

Lewy bodies (α-synuclein)

DA neurons (substantia nigra pars compacta)

Huntington’s disease

Aggregated huntingtin (mutated huntingtin)

MSN neurons (striatum)