From: Towards physiologically relevant human pluripotent stem cell (hPSC) models of Parkinson’s disease
Protein inclusion | Most vulnerable neuronal population | |
---|---|---|
Alzheimer’s disease | Neurofibrillary tangles (phosphorylated tau); amyloid plaques (amyloid β peptide) | Pyramidal neurons (entorhinal cortex, hippocampus, locus coeruleus) |
Parkinson’s disease | Lewy bodies (α-synuclein) | DA neurons (substantia nigra pars compacta) |
Huntington’s disease | Aggregated huntingtin (mutated huntingtin) | MSN neurons (striatum) |