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Table 3 Neurodegenerative disease unique protein aggregates and neuronal susceptibility

From: Towards physiologically relevant human pluripotent stem cell (hPSC) models of Parkinson’s disease

  Protein inclusion Most vulnerable neuronal population
Alzheimer’s disease Neurofibrillary tangles (phosphorylated tau); amyloid plaques (amyloid β peptide) Pyramidal neurons (entorhinal cortex, hippocampus, locus coeruleus)
Parkinson’s disease Lewy bodies (α-synuclein) DA neurons (substantia nigra pars compacta)
Huntington’s disease Aggregated huntingtin (mutated huntingtin) MSN neurons (striatum)