Fig. 5
Effect of HMW HA Primed MSC EV on Inflammatory Cell Infiltration into the Injured Alveolus. a There were no significant differences in the total white blood cell (WBC) nor absolute neutrophil (ANC) counts in either the BALF or plasma. Data are mean ± SD, N = 6–20. b By histology, administration of MSC EV reduced alveolar inflammatory cells infiltration, interstitial wall thickening, and blood/edema, which was further reduced with HMW HA primed MSC EV. Lung injury assessed by semiquantitative scoring was decreased by MSC EV and further reduced with HMW HA primed MSC EV. Magnification × 4, Bar = 1 mM. Data are as mean ± SD, ***P < 0.001, ****P < 0.0001 by ANOVA (Bonferroni), N = 20. A dose of MSC EV (90 μl) was used = 2.0 × 1010 particles