Fig. 6

Trafficking of MSC EV With or Without HMW HA in Mice with PA103 Bacterial Pneumonia. Intravenous administration of HMW HA (1.0 MDa) primed MSC EV increased trafficking of MSC EV to the lung, liver, and spleen. a Representative immunofluorescence from each organ with treatment of HMW HA (1.0 MDa) primed MSC EV or MSC EV alone. Magnification 4X, Bar = 1 mM. b Quantification of the fluorescent intensity. Data is mean ± SD, ***P < 0.001, ****P < 0.0001 by Student’s t test, N = 12–16. A dose of MSC EV (90 μl) was used = 2.0 × 10¹⁰ particles