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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Human bone marrow-derived, pooled, allogeneic mesenchymal stromal cells manufactured from multiple donors at different times show comparable biological functions in vitro, and in vivo to repair limb ischemia

Fig. 4

a Stempeucel® improves limb functionality and protects from foot necrosis in HLI mouse model: a Treatment with both Stempeucel®-1 and Stempeucel®-1A can salvage limbs in HLI BALB/c mouse model. Representative photographs of sham control, vehicle control, and Stempeucel®-treated animals from day 0 to 28 are shown. Stempeucel® improves limb functionality and protects from foot necrosis in HLI mouse model: b Mean ambulatory and; c necrotic score in sham control, vehicle control, Stempeucel®-1- and Stempeucel®-1A-treated animals at different time points; necrotic score-Stempeucel®-1 and Stempeucel®-1A ***P < 0.001 versus the vehicle control group. d Percentage of mice completely protected from foot necrosis in sham control, vehicle control, and Stempeucel®-1- and Stempeucel®-1A-treated animals at different time points; Stempeucel®-1- ***P < 0.001, Stempeucel®-1A- ***P < 0.001 versus vehicle-injected group

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Stem Cell Research & Therapy

ISSN: 1757-6512