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Table 2 Predicted consequential pairing of target region in the transcript and miR-424-5p

From: Upregulated anti-angiogenic miR-424-5p in type 1 diabetes (model of subclinical cardiovascular disease) correlates with endothelial progenitor cells, CXCR1/2 and other parameters of vascular health

Target gene

Representative transcript

Gene name

Transcript position

Predicted consequential pairing of target region Transcript (top) and miRNA (bottom)

Site type

CCND1

ENST00000227507.2

Cyclin D1

1961–1967 3′UTR

(Transcript)

5′ CCAUUUUCUUAUUGCGCUGCUAC 3′

(miRNA)

3′ AAGUUUUGUACUUAACGACGAC 5′

7mer-A1

   

2033–2040 3′UTR

(Transcript)

5′ CUCUUUCACAUUGUUUGCUGCUA 3′

(miRNA)

3′ AAGUUUUGUACUUAACGACGAC 5′

8mer

VEGFA

ENST00000372067.3

Vascular endothelial growth factor A

276–283 3′UTR

(Transcript)

5′CCAUUUUAUUUUUCUUGCUGCUA 3′ (miRNA)

3′ AAGUUUUGUACUUAACGACGAC 5′

8mer

CD40

ENSG00000101017

CD40, TNF receptor superfamily member 5

61–71

3′UTR

(Transcript)

5′ CUUCCUGGCUCCAACACUGCUGCUC 3′

(miRNA)

3′ AAGUUUUGUACUUAACGACGAC 5′

7mer

COX2

ENSG00000073756 (PTGS2)

Cyclooxygenase-2

165–179

3′UTR

(Transcript)

5′ UGAUUUGUUAUUAACAUUGAUCGCUG 3′

(miRNA)

3′ AAGUUUUGUACUUAACGACGAC 5′

6mer

INSR

ENSG00000171105

Insulin receptor

4218–4241

3′UTR

Transcript)

5′UCCUCAAAUUGACCAAUAGCUGCUGC 3′

(miRNA)

3′ AAGUUUUGUACUUAACGACGAC 5′

7mer

   

3844–3871

3′UTR

(Transcript)

5′UCAUCAUGAUCACUGAUUACUUGCUGCUC3′

(miRNA)

3′ AAGUUUUGUACUUAACGACGAC 5′

8mer

  1. TargetScan Human, release 7.1 (www.targetscan.org) and Diana-TarBase v8 (http://carolina.imis.athena-innovation.gr/diana_tools/web/index.php?r=tarbasev8%2Findex) databases were used to predict the interaction sites between the transcripts and miR-424-5p