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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Consecutive daily administration of intratracheal surfactant and human umbilical cord-derived mesenchymal stem cells attenuates hyperoxia-induced lung injury in neonatal rats

Fig. 7

Representative western blots and quantitative data determined with densitometry for PDGF-A and PDGF-B protein expression in 14-day-old rats exposed to postnatal RA or hyperoxia and treated with NS or surfactant on postnatal day 4 and NS or MSCs (3 × 104 or 3 × 105 cells) on postnatal day 5. The rats reared in hyperoxia and treated with NS exhibited significantly lower PDGF-A and PDGF-B protein expression levels than those reared in RA and treated with NS or surfactant. Treatment with surfactant and hUC-MSCs (3 × 105 cells) more significantly augmented the hyperoxia-induced decrease in the PDGF-A and PDGF-B protein expression levels than did the treatment with NS. Data are shown as box-and-whisker plots. *P < 0.05 and **P < 0.01. MSCs mesenchymal stem cells, NS normal saline, O2 oxygen-enriched atmosphere, PDGF platelet-derived growth factor, RA room air, S surfactant

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