Fig. 8
Lung IL-1β and IL-6 levels in 14-day-old rats exposed to postnatal RA or hyperoxia and treated with NS or surfactant on postnatal day 4 and NS or hUC-MSCs (3 × 104 cells or 3 × 105 cells) on postnatal day 5. The rats reared in hyperoxia and treated with NS yielded a significantly higher IL-1β and IL-6 levels than did those reared in RA and treated with NS or surfactant. Treatment with surfactant and surfactant + hUC-MSCs (3 × 104 or 3 × 105 cells) significantly reduced the hyperoxia-induced increase in the IL-1β and IL-6 levels. Data are shown as box-and-whisker plots. **P < 0.01 and ***P < 0.001. S: surfactant. MSCs mesenchymal stem cells, NS normal saline, O2 oxygen-enriched atmosphere, RA room air, S surfactant