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Table 1 Body and lung weights and lung-to-body-weight ratios in 14-day-old rats exposed to RA or hyperoxia and treated with NS or surfactant on postnatal day 4 and NS or MSCs on postnatal day 5

From: Consecutive daily administration of intratracheal surfactant and human umbilical cord-derived mesenchymal stem cells attenuates hyperoxia-induced lung injury in neonatal rats

Treatment n Body weight Lung weight Lung to body weight ratio
   (g) (g) (%)
RA + NS + NS 13 23.62 ± 2.57 0.41 ± 0.03 1.74 ± 0.21
RA + surfactant + NS 11 25.75 ± 4.94 0.45 ± 0.06 1.79 ± 0.20
O2 + NS + NS 5 23.22 ± 7.01 0.39 ± 0.17 1.64 ± 0.50
O2 + surfactant + NS 8 22.83 ± 4.62 0.42 ± 0.09 1.86 ± 0.26
O2 + surfactant + hUC-MSCs (3 × 104) 8 24.39 ± 7.07 0.46 ± 0.12 1.94 ± 0.47
O2 + surfactant + hUC-MSCs (3 × 105) 5 23.41 ± 1.67 0.40 ± 0.04 1.70 ± 0.13
  1. Values are presented as means ± standard deviations
  2. hUC-MSCs human umbilical cord-derived mesenchymal stem cells, NS normal saline, O2 oxygen-enriched atmosphere, RA room air
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Stem Cell Research & Therapy

ISSN: 1757-6512