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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: PRL-1 overexpressed placenta-derived mesenchymal stem cells suppress adipogenesis in Graves’ ophthalmopathy through SREBP2/HMGCR pathway

Fig. 3

hPMSCsPRL-1 inhibit adipogenesis in GO animal models. a Quantification of white adipose tissues area stained with perilipin, an adipocyte marker, was measured around optic nerve of GO models at 1 week post-transplantation (n = 3/each group). b Adipogenesis-related genes such as C/ebpα, leptin, adiponectin, and Fabp4 mRNA were determined (n = 6/each group). c Leptin levels in serum of GO models were measured (n = 6/each group). Data was presented as the fold changes (means ± SEM). Significantly different values between groups are indicated with asterisk (*p < 0.05, ***p < 0.001 vs age-matched sham; ##p < 0.05 vs hPMSCs)

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