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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Cardiac organoid — a promising perspective of preclinical model

Fig. 2

Construction methods and applications of human cardiac organoids. The human cardiac organoid consists of different cardiac lineage cells derived from human pluripotent stem cells. By utilizing diversified bioengineering techniques, cardiac organoids have the ability to simulate some key characteristics of the heart. Cardiac organoids hold promise as tools to model diseases and predict drug responses, and as sources for heart transplantation and cardiac development research. Many other potential applications for preclinical use of this technology await discovery. hPSC-CMs, human pluripotent stem cell-derived cardiomyocytes; hPSC-ECs, human pluripotent stem cell-derived endothelial cells; hPSC-FBs, human pluripotent stem cell-derived fibroblasts

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