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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: The role of Serpina3n in the reversal effect of ATRA on dexamethasone-inhibited osteogenic differentiation in mesenchymal stem cells

Fig. 4

Effects of ATRA on GIOP rat model in vivo. a–e Serum concentrations of ALP, calcium, phosphorus, OCN, and TRACP-5b in different groups, *p < 0.05 vs DEX, **p < 0.01 vs DEX. f H&E and Masson’s trichrome staining showed the effect of ATRA on DEX-induced GIOP rats. g μCT and three-dimensional reconstruction of vertebrae demonstrated the effect of ATRA on DEX-induced GIOP rats. h ROI analysis of vertebrae showed the effect of ATRA on DEX-induced GIOP rats, *p < 0.05, **p < 0.01. OCN, osteocalcin; TRACP-5b, tartrate-resistant acid phosphatase 5b; ROI, region of interest; BV/TV, ratio of bone volume to total volume; Tb.N, trabecular number; Tb.Th, trabecular thickness; Tb.Sp, trabecular separation; LP: prevention with low concentration of ATRA; MP: prevention with medium concentration of ATRA; HP: prevention with high concentration of ATRA; LT: treatment with low concentration of ATRA; MT: treatment with medium concentration of ATRA; HT: treatment with high concentration of ATRA

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Stem Cell Research & Therapy

ISSN: 1757-6512