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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Liver development is restored by blastocyst complementation of HHEX knockout in mice and pigs

Fig. 1

Characterization of the HHEX KO mouse embryos compared to WT. a Phenotype of the Hhex KO E9.5 and E10.5 mice. Separation between orange bars is 1 mm. b IHC images of E9.5 Hhex KO mouse with Hoechst (blue), anti-HHEX (red), and anti-cTnT (green) antibodies. Bars, 100 μm. cg Gene expression analyses (RNA-seq, cf; qRT-PC, g) in the Hhex KO E9.5 mice vs WT (N = 3 each group). c Principal component analysis. d Heatmap showing all the significantly up- and downregulated genes. e Heatmap showing liver-related genes whose expressions are significantly up- or downregulated. f Volcano plot showing significantly up- and downregulated genes (both in blue) and unaffected genes (orange), highlighting some liver-related genes. g Relative expression of transcripts. *p < 0.05

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