Fig. 4
Cav1 participates in the improvement of CCl4-injured liver fibrosis after hPMSCs treatment. a Heatmap showing the differentially expressed genes (DEGs) among liver tissues from hPMSC group, normal, and fibrosis group (log2 fold change ≥ 2, p < 0.05). b–d Heatmaps of three key gene clusters associated with liver fibrosis. e GO analysis (biological processes) of significantly downregulated DEGs between hPMSC group and fibrosis group. (p < 0.05). f Expression of ten fibrosis-related genes at different groups was determined using qRT-PCR. Relative mRNA expression was normalized to β-actin and compared with the fibrosis group. Mice from fibrosis group received PBS followed by CCl4 injection. ***p < 0.001, **p < 0.01, *p < 0.05; ns, no significance; Cav1, Caveolin-1