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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Human placental mesenchymal stem cells ameliorate liver fibrosis in mice by upregulation of Caveolin1 in hepatic stellate cells

Fig. 6

Upregulation of Cav1 after hPMSCs treatment was important in relieving liver fibrosis and inhibition of activated HSCs. a Immunohistochemistry staining using anti CAV1 antibody in liver sections. b Immunofluorescence staining using anti CAV1 antibody in HSCs. c, d Expression of fibrosis-related genes (c) and TGF-β/Smad signaling pathway related genes (d) at different groups was determined using qRT-PCR. Relative mRNA expression was normalized to β-actin and compared with the NC group. Cells from blank group were unactivated HSCs, cells from si (1-3) group or NC group were HSCs that transfected with Cav1 siRNA (1-3) or Cav1 siRNA-negative control. Scale bar, 50 μm. ****p < 0.0001, ***p < 0.001, **p < 0.01, *p < 0.05; ns, no significance

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Stem Cell Research & Therapy

ISSN: 1757-6512