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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Mesenchymal stem cell-derived microvesicles improve intestinal barrier function by restoring mitochondrial dynamic balance in sepsis rats

Fig. 1

The intestinal barrier function was impaired after sepsis. a EB leakage of intestine at different times after sepsis (n=8). b Wet weight to dry weight ratio of intestine at different times after sepsis (n=8). c Blood D-lac level at different times after sepsis (n=8). d Blood TNFα level at different times after sepsis (n=8). e Blood Zonulin level at different times after sepsis (n=8). f Representative microphotographs of HE staining in intestine. The scale bar represents 100μm. g The relative expression of PCNA in intestine at different times after sepsis. β-actin was used as the internal reference (n=5). h TEER of IEC-6 after LPS stimulation (n=5). i BSA leakage of IEC-6 after LPS stimulation (n=6). j CCK8 proliferation assay of IEC-6 (n=6). k Representative microphotographs of the scratch migration assay and the scratched area were shown. The scale bar represents 100μm. l The relative expression of PCNA in IEC-6 after LPS stimulation. β-actin was used as the internal reference (n=5). m Representative IF microphotographs of ZO-1 in IEC-6 after LPS stimulation. The scale bar represents 20μm. n Representative IF microphotographs of Tunel assay in IEC-6. The scale bar represents 50μm. Ctl, normal control group; C8h, 8h after CLP group; C16h, 16 h after CLP group; C24h, 24h after CLP group. **P < 0.01, *P < 0.05

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