Fig. 4

Teratoma capacity of a healthy donor and GS-2 iPSCs. a 1 × 10⁶ healthy donor iPSCs were injected intramuscularly in Rag2^−/− mice and followed for 6–8 weeks. Mice were sacrificed when palpable tumors appeared. Teratomas were fixed and stained with hematoxylin/eosin. Teratomas reveal the presence of mesodermal striated muscle (SM), adipose tissue (AT), cartilage (Ca), blood vessel (BV), endodermal respiratory (REp) and gastrointestinal (GEp) epithelium, and ectodermal axons (Ax). b 1 × 10⁶ GS-2 iPSCs were injected intramuscularly in Rag2^−/− mice. Teratomas reveal the presence of mesodermal striated muscle (StM) and smooth muscle (SmM), blood vessel (BV), cartilage (Ca), endodermal respiratory endothelium (RE), and ectodermal epidermis (Epi). Pictures from representative samples