Fig. 2

Conditioned medium of iMSCs effectively accelerated cutaneous wound healing. a Schematic diagram of animal study. Conditioned medium of mesenchymal stem cells derived from umbilical cord mesenchymal stem cells (uMSC-CdM) and conditioned medium of mesenchymal stem cells derived from induced pluripotent stem cells (iMSC-CdM) was applied daily after the surgery. b Schematic diagram depicting delivery method of uMSC-CdM/iMSC-CdM. A sterile cotton pad (blue box) was placed to cover the wound area (red circle) and then uMSC-CdM or iMSC-CdM was topically administered onto the pad. c Representative images of the wounds receiving conditioned medium treatment were taken 1 and 9 days after surgery. Scale bar = 1 cm. d The recovery rate was measured daily after treatment. *P < .05 iMSC-CdM vs control group; **P < .01 iMSC-CdM vs control group; ***P < .001 iMSC-CdM vs control group; ^#P < .05 uMSC-CdM vs control group; †P < .05 iMSC-CdM vs uMSC-CdM group