Fig. 4
The cytoprotective effects of iMSC-CdM on H2O2 treated HUVECs. After H2O2 treatment, a apoptosis, b cell reactive oxygen species, c mitochondrial reactive oxygen species, and d mitochondrial permeability transition pore (mPTP) opening were determined by flow cytometry. MFI, mean fluorescent intensity. ns, non-significance, *P < .05, **P < .01, ***P < .001. e Cell proliferation was determined by Cell Counting Kit–8 assay. *P < .05 iMSC-CdM vs control group; #P < .05 uMSC-CdM vs control group; †P < .05 iMSC-CdM vs uMSC-CdM group. f Representative light photomicrographs and quantitative analysis of HUVEC tube formation assay after uMSC-CdM/iMSC-CdM treatment. Scale bar = 100 μm. *P < .05, **P < .01. g Protein concentration and expression levels of angiogenic factors in uMSC-CdM and iMSC-CdM. ***P < .001