Fig. 6

ADM2 reversed the imbalance of M1/M2 polarization during distraction osteogenesis in diabetic rats. A Immunofluorescence staining images of CD68 and CD86 for the distraction area sections from the four groups. Scale bar 100 μm. B Quantitative analysis of CD68⁺CD86⁺/CD68⁺ M1 macrophage ratio for the distraction area sections from the four groups. C Immunofluorescence staining images of CD68 and CD206 for the distraction area sections from the four groups. Scale bar 100 μm. D Quantitative analysis of CD68⁺CD206⁺/CD68⁺ M2 macrophage ratio for the distraction area sections from the four groups. The data were confirmed by one-way analysis of variance (ANOVA) followed by Tukey’s post hoc test from three independently repeated tests and are presented as the means ± SD. *P < 0.05; **P < 0.01