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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: RETRACTED ARTICLE: Mesenchymal stem cell-derived exosomal miR-146a reverses diabetic β-cell dedifferentiation

Fig. 3

MiR-146a in bmMDEs reverses β-cell dedifferentiation. a Heat map of miRNA sequencing showing the differently expressed miRNAs in IDEs, HG IDEs, and bmMDEs. b RT-qPCR verification of the expression levels of the top 10 differential miRNAs. c A GSIS assay was performed to detect insulin stimulation in HG-treated INS-1 cells transfected with the top 10 differential miRNA mimics. Levels of miR-146a in INS-1 cells (d) and islets (e) treated with bmMDEs. RT-qPCR analyses for Pdx1, Foxo1, Ngn3, and Oct4 in islets (fi) transfected with an miR-146a mimic or miR-NC mimic as indicated. mRNA expression levels of Pdx1, Foxo1, Ngn3, and Oct4 in islets (jm) transfected with an miR-146a inhibitor or miR-NC inhibitor as indicated. Data are presented as the mean ± SEM (P < 0.05; P < 0.01; ***P < 0.001)

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