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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: The stromal vascular fraction mitigates radiation-induced gastrointestinal syndrome in mice

Fig. 1

Identification of irradiation dose inducing GIS. a Kaplan-Meier survival analysis of 16, 18, 20 and 22 Gy abdominal irradiated mice (n = 10 per group). b Weight loss changes for 30 days of mice exposed to 16, 18, 20 and 22 Gy abdominal irradiation (n = 10 per group). c Response of the small intestine to 16, 18, 20 and 22 Gy abdominal irradiation at day 3.5. Representative HES staining of the ileum showing structural modification. Scale bar 100 μm. d Irradiation dose-dependent regenerative crypts. The plots illustrate the number of surviving regenerative crypts present by unit length in a small intestine 3.5 days post-irradiation. The data are represented by mean ± SEM (n = 4–5), p values were calculated by one-way or two-way analyses (for weight loss changes) of variance (ANOVA) with Bonferroni correction; *p < 0.01; **p < 0.001 compared with the control group. e Tunel staining. Representative images of ileal sections at 3.5 days post-irradiation demonstrating an increase of Tunel-positive cells at the crypt base with the escalating dose from 16 to 22 Gy. Tunel-positive cells were stained green and the nucleus was stained with DAPI at day 3.5 post-irradiation. Scale bar 50 μm

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