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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Hypoxic mesenchymal stem cells ameliorate acute kidney ischemia-reperfusion injury via enhancing renal tubular autophagy

Fig. 1

Characteristics and tracking of hypoxic rat mesenchymal stem cells (HMSCs) in ischemia-reperfusion injured rat kidneys. a HMSCs from the bone marrow of adult Sprague-Dawley rats were analyzed for the expression of surface markers (red lines) by flow cytometry. Gray shaded areas indicate unstained controls. b HMSCs had adipogenic, chondrogenic, and osteogenic differentiation abilities. Scale = 100 μm. c The rats with renal ischemia-reperfusion injury were administered with PKH67-labeled HMSCs or phosphate-buffered saline (PBS) via intra-renal arterial (IA) or intraperitoneal (IP) routes and sacrificed 48 h later. Fluorescence microscopy analysis revealed that PKH67-labeled HMSCs (arrowheads) retained the I/R-injured rat kidneys. n = 2 per group. Scale = 50 μm

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