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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Human amnion-derived mesenchymal stem cells improved the reproductive function of age-related diminished ovarian reserve in mice through Ampk/FoxO3a signaling pathway

Fig. 2

Establishment of age-related diminished ovarian reserve (AR-DOR) mouse model. a The litter size and serum level of hormones (by ELISA kit) were analyzed to access ovarian function. The litter size and levels of AMH and E2 were significantly decreased in AR-DOR mice and the level of FSH was increased in AR-DOR mice. b Histological analysis of paraffin-embedded sections and hematoxylin and eosin (HE) staining on mouse ovaries. The number of secondary and antral follicles was significantly decreased in AR-DOR mice. AMH: anti-Mullerian hormone; E2: estradiol; FSH: follicle stimulating hormone. AF: antral follicle; SF: secondary follicle. Scale bar 500 μm. n = 8. Error bars indicate SEM. Different lowercase letters represent significantly statistical differences (P < 0.05)

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Stem Cell Research & Therapy

ISSN: 1757-6512