Fig. 5

hAMSC transplantation repressed apoptosis of ovarian cells in AR-DOR mice. a Histological analysis on mouse ovary was carried out by TUNEL assay and microscope observation. Less apoptotic granulosa and stromal cells were observed in hAMSC-transplanted groups (LD, MD, and HD). Triangles indicate apoptotic granulosa cells. Arrows indicate apoptotic stromal cells. b Apoptosis rates of granulosa cells, theca cells, and stromal cells were calculated in groups. The rates of apoptosis in granulosa and stromal cells were significantly decreased in the MD and HD groups. The rate of apoptosis in theca cells was significantly decreased in the HD group. NS: normal saline group; HSA: 1% human serum albumin group; LD: low-dose group; MD; middle-dose group; HD: high-dose group. Scale bar 100 μm. n = 8. Error bars indicate SEM. Different lowercase letters represent significantly statistical differences (P < 0.05)