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Fig. 11 | Stem Cell Research & Therapy

Fig. 11

From: Bone marrow mesenchymal stem cells and their derived exosomes resolve doxorubicin-induced chemobrain: critical role of their miRNA cargo

Fig. 11

Effects of bone marrow stem cell (BMSC) and their exosome (BMSCs-Exo) treatment on inflammatory, apoptotic, and oxidative stress markers in doxorubicin (DOX)-induced chemobrain in rats. A A bar chart representing the protein expression of interleukin (IL)-6 in different rat groups. B A bar chart representing the protein expression of tumor necrosis factor (TNF)-α in different rat groups. C A bar chart representing the % of mRNA expression induction of Cx3cr1 in different rat groups. D A bar chart representing the % of mRNA expression induction of BAX in different rat groups. E A bar chart representing the % of mRNA expression induction of Bcl-2 in different rat groups. F A bar chart representing BAX/Bcl2 ratio in different rat groups. G A bar chart representing the abundance of glutathione (GSH) in brains of different rat groups. H A bar chart representing the activity of glutathione peroxidase enzyme (GPx) in brains of different rat groups. I A bar chart representing the activity of superoxide dismutase enzyme (SOD) in brains of different rat groups. Data are presented as mean ± SEM. Statistical Analysis was performed using one-way ANOVA followed by Tukey’s post hoc test (n = 6). a Significantly different from the control group at p < 0.05. b Significantly different from the DOX group at p < 0.05

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