Skip to main content
Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Bone marrow mesenchymal stem cells and their derived exosomes resolve doxorubicin-induced chemobrain: critical role of their miRNA cargo

Fig. 3

Bone marrow stem cell (BMSC) and their exosome (BMSCs-Exo) treatment reverse behavioral changes induced by doxorubicin (DOX) in rats. A, B Box plots representing results from step-through passive avoidance behavioral test. C A scatter plot representing results from Morris water maze test. D A bar chart representing results from the probe test. E A bar chart representing Y-maze % of alternation (SAP). F A bar chart representing Y-maze total arm entries (TAE). G A scatter plot representing the correlation between SAP and TAE and H a bar chart representing results from the locomotor activity test. For A and B, data are presented as medians (25th, 75th percentile) and statistical analysis was carried out using Kruskal–Wallis non-parametric test followed by Dunn’s test (n = 8). For CH, data are presented as mean ± SEM (n = 8). For C, statistical analysis was performed using repeated two-way ANOVA followed by the Bonferroni post-tests as post hoc test. For D–F and H, statistical analysis was performed using one-way ANOVA followed by Tukey’s test as post hoc test (n = 8). a Significantly different from the control group at p < 0.05. b Significantly different from DOX group at p < 0.05. For G, statistical analysis was performed using Pearson’s correlation

Back to article page