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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Bone marrow mesenchymal stem cells and their derived exosomes resolve doxorubicin-induced chemobrain: critical role of their miRNA cargo

Fig. 4

Histopathological analysis of rat brain sections using H&E staining. Lane (1) (× 100): Neuroanatomy of brain areas being investigated to show brain structures in the representative micrographs. Lane (2) (× 400): A Control group showed normal histological structure of the neurons in the subiculum. B DOX-induced chemobrain group showed nuclear pyknosis and degeneration observed in diffuse manner all over the neurons in the subiculum (arrow). C BMSC-treated DOX group showed normal subiculum histological features. D BMSCs-Exo treated DOX group showed no histological alterations in the subiculum regions. Lane (3) (× 400): A the control group showed normal histological structure of the neurons in the fascia dentata and hilus of the hippocampus. B DOX-induced chemobrain group showed nuclear pyknosis and degeneration observed in fascia dentata and hilus (arrow) of the hippocampus. C BMSC-treated DOX group showed few nuclear pyknosis and degeneration in fascia dentata and hilus of the hippocampus (arrow). D BMSCs-Exo-treated DOX group showed nuclear pyknosis and degeneration was shown in some neurons in fascia dentata and hilus of the hippocampal region (arrow) (n = 4)

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Stem Cell Research & Therapy

ISSN: 1757-6512