Fig. 5

Bone marrow stem cell (BMSC) and their exosome (BMSCs-Exo) treatment reverse neural damage induced by doxorubicin (DOX) in rats. Representative images of toluidine blue-stained brain tissue sections (× 400) of A the control group showing normal histological structure showing intact neurons in CA1 region, B DOX-induced chemobrain group showing decrease in intact neuron in CA1 region, C BMSC treatment group showing significant restoration in intact neurons in CA1 region, and D BMSCs-Exo treatment group showing significant restoration in intact neurons in CA1 region. E A bar chart reflecting the quantitative image analysis for intact neurons in CA1 region expressed intact cell number per field. Representative images of toluidine blue-stained brain tissue sections (× 400) of F control group showing normal histological structure showing intact neurons in CA3 region, G DOX-induced chemobrain group showing decrease in intact neuron in CA3 region, H BMSC treatment group showing significant restoration in intact neurons in CA3 region, and I BMSCs-Exo treatment group showing significant restoration in intact neurons in CA3 region. J A bar chart reflecting the quantitative image analysis for intact neurons in CA3 region expressed intact cell number per field. For E and J, statistical analysis was performed using one-way ANOVA followed by Tukey’s test as post hoc test (n = 4). Data are presented as mean ± SEM. ^a Significantly different from the control group at p < 0.05. ^b Significantly different from DOX group at p < 0.05