Fig. 6

Bone marrow stem cell (BMSC) and their exosome (BMSCs-Exo) treatment prevent neural demyelination induced by doxorubicin (DOX) in rats. Representative images of Luxol fast blue-stained sections (× 100 and × 400) of A the control group showing positive stained myelinated nerve fibers in the corpus callosum region, B DOX-induced chemobrain group showing decrease in positively stained myelinated nerve fibers in the corpus callosum region, C BMSC treatment group showing restoration of positively stained myelinated nerve fibers in the corpus callosum region, and D BMSCs-Exo treatment group showing restoration of positively stained myelinated nerve fibers in the corpus callosum region. E A bar chart reflecting the quantitative image analysis for positive stained myelinated nerve fibers in the corpus callosum region expressed as area percent. F A bar chart representing the % of mRNA expression induction of Opalin in different rat groups. G A bar chart representing the % of mRNA expression induction of Olig-2 in different rat groups. For E, F, and G, statistical analysis was performed using one-way ANOVA followed by Tukey’s test as post hoc test (n = 6). Data are presented as mean ± SEM. ^a Significantly different from the control group at p < 0.05. ^b Significantly different from the DOX group at p < 0.05